The utility of cell-free nucleic acids in monitoring cancer has been recognized by both scientists and clinicians. In addition to human transcripts, a fraction of cell-free nucleic acids in human plasma were proven to be derived from microbes and …
Microbial strains of variable functional capacities coexist in microbiomes. Current bioinformatics methods of strain analysis cannot provide the direct linkage between strain composition and their gene contents from metagenomic data. Here we present …
The dysbiosis of gut microbiota is associated with the pathogenesis of human disease. However, observing shifts in the microbe abundance cannot fully reveal underlying perturbations. Examining the relationship alteration (RA) in the microbiome …