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PM2RA: A Framework for Detecting and Quantifying Relationship Alterations in Microbial Community

The dysbiosis of gut microbiota is associated with the pathogenesis of human disease. However, observing shifts in the microbe abundance cannot fully reveal underlying perturbations. Examining the relationship alteration (RA) in the microbiome …

An Examination of Data from the American Gut Project Reveals That the Dominance of the Genus Bifidobacterium Is Associated with the Diversity and Robustness of the Gut Microbiota

Bifidobacterium and Lactobacillus are beneficial for human health, and many strains of these two genera are widely used as probiotics. We used two large datasets published by the American Gut Project (AGP) and a gut metagenomic dataset (NBT) to …